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  • Understanding Negative Peaks in ESI-MS

    May 28, 2025
    Troubleshooting

    I recently coupled an old MSD to an SFC system and after tuning the MSD, I tried a sample run in positive mode. This is when I observed my MS peaks were going down. These negative peaks would usually indicate that the signal from the background or solvent is greater than the signal from the…

  • Mass balance in chemical and pharmaceutical Analysis

    Mass balance in chemical and pharmaceutical Analysis

    April 4, 2025
    Fundamentals

    Mass balance is a fundamental concept in chemical and pharmaceutical sciences, ensuring accuracy in quantifying chemical yields and assessing degradation. But what exactly is mass balance, and why is it so crucial for analysts? Mass balance definition At its core, mass balance applies the Law of Conservation of Mass, allowing scientists to sum assay values…

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